Effects of running on cartilage in those with and without knee osteoarthritis

Who can participate?

We are currently recruiting women aged 40 years and older with and without knee osteoarthritis (OA) who have been running at least 10 km per week for a minimum of 2 years. You must be comfortable running on a treadmill for at least 30 minutes. You may be included in the group of runners with knee OA if you have experienced knee pain for at least 3 months during your daily activities (not just during running) and show evidence of knee OA on x-ray. You may be included in the group of runners without knee OA if you have no evidence of knee OA on x-ray. If you do not have recent x-ray images of your knees, they will be obtained to determine your study eligibility.

What is required?

Your participation in this study will consist of two testing sessions at UBC Hospital. The first session will involve a clinical examination of your knee and a 3D walking assessment. The second session will include magnetic resonance imaging (MRI) of your knee, before running on a treadmill for 30 minutes. After the run, you will be transferred for a second and third MRI of your knee. The time commitment for the first session is approximately 1.5 hours, and approximately 4 hours are required for the second session.

If you would like to register your interest in this study, please complete the eligibility form below.